Applying single-molecule optical and AFM imaging and drive-spectroscopy techniques, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate interests incorporate:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I
Sad to say, For many years just after Iijima’s report, the manufacture of clean up nanotubes was cumbersome. In 1996, even so, the team of Richard Smalley at Rice University managed to generate single-walled carbon nanotubes at significant yield. Soon just after, I contacted Smalley, and we chose to sign up for forces to measure the transport by way of a one carbon nanotube.
This yielded a breakthrough. In just a few months, we have been ready to evaluate transportation by way of someone solitary-walled carbon nanotube. According to lower-temperature experiments by an excellent PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Engineering having an active investigation lab at AMOLF in Amsterdam), we showed that carbon nanotubes had been legitimate quantum wires with very extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
The coiled-coil of the human Rad50 DNA maintenance protein is made up of certain segments of greater versatility
What distinguishes biology from chemistry is these factors jointly make up a residing system. The trick of mentioned life, I feel, lies in the interactions, the interaction of These molecules. The large issue concerning the origin of life remains to ceesdekker.net be unanswered. How did we ever evolve from simple molecules in the very advanced systems we see nowadays? We do not know. I want to operate on These types of large, open up questions.’
Dynamic ParB–DNA interactions initiate and manage a partition condensate for bacterial chromosome segregation
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Presently, we also understood that it ought to be attainable to work with an individual semiconducting carbon nanotube to generate a transistor — and we set out to make it. We stretched individual semiconducting nanotubes throughout metallic electrodes and applied the fundamental silicon substrate like a gate electrode, establishing the basic a few-terminal layout of the industry-influence transistor (Fig.
In 1993 he was appointed as Associate Professor at Delft College of Technological know-how. Inside the mid-nineties Dekker and his workforce realized achievement with the invention from the electronic Qualities of carbon nanotubes, the very first single-molecule transistor and also other nanoscience.
1999, initial measurement of your wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for the new Luttinger description of interacting electrons in nanotubes
2008, initially observation of protein-coated DNA translocation as a result of nanopores; fixed the origin on the electrophoretic pressure on DNA in nanopores; found a significant velocity improve of microtubules in electric fields; discovered an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of noise in carbon nanotubes in liquid
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent structure in 2005. (nl)